The Coming of Age of De Novo Protein Design

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The William H. Stein Memorial Lecture

Event Details

David Baker, Ph.D., head, Institute for Protein Design; professor of biochemistry, University of Washington; investigator, Howard Hughes Medical Institute

Proteins mediate the critical processes of life and beautifully solve the challenges faced during the evolution of modern organisms. The goal of the Baker Lab is to design a new generation of proteins that address current day problems not faced during evolution. In contrast to traditional protein engineering efforts, which have focused on modifying naturally occurring proteins, the lab designs new proteins from scratch based on Anfinsen’s principle that proteins fold to their global free energy minimum. They compute amino acid sequences predicted to fold into proteins with new structures and functions, produce synthetic genes encoding these sequences, and characterize them experimentally. Dr. Baker will describe the de novo design of fluorescent proteins, new protein therapeutic candidates, membrane penetrating macrocycles, transmembrane protein channels, protein delivery vehicles, and allosteric proteins that carry out logic operations.

Justin Sloboda
(212) 327-7785
Open to
Refreshments, 3:15 p.m. - 3:45 p.m., Abby Lounge
Justin Sloboda
(212) 327-7785

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