Grant Will Define Skin and Blood Biomarkers of Pediatric Atopic Dermatitis
– May 13, 2014 /Press Release/ ––
Despite considerable impact on quality of life, atopic dermatitis, or eczema, has not been studied extensively in children, although as many as one-in-five have eczema. We are proud to announce that one of the top researchers worldwide in the study of eczema, Emma Guttman, MD, PhD, Associate Professor and Director of the Laboratory for Inflammatory Skin Diseases, at the Icahn School of Medicine at Mount Sinai, will investigate blood biomarkers important in promoting and maintaining eczema in children.
The LEO Foundation has awarded Dr. Guttman an $846,400 grant for research into to examine the skin and blood biomarkers of atopic dermatitis in children.
Dr. Guttman will investigate how well skin biomarkers compare with disease activity, epidermal barrier function, and known biomarkers in the adults with atopic dermatitis. They will also investigate whether blood biomarkers could offer a less invasive way to monitor skin changes than a skin biopsy, which can be difficult to perform in children.
With better knowledge of what causes atopic dermatitis in children, the researchers hope to develop more targeted therapies for the disorder, as well as for other atopic diseases, such as asthma and hay fever. Together, these three disorders form an “atopic triad.”
“Winning this grant will allow us to understand how atopic dermatitis is initiated and sustained in children,” said Dr. Guttman, whose research in atopic dermatitis has been pivotal in the field. “Even though 85 percent of individuals with atopic dermatitis develop it in the first five years of life, causes of it in children have received virtually no attention,” added Dr. Guttman.
Atopic dermatitis or eczema is a chronic disease of the skin, characterized by itching and inflammation that frequently occur in people who have other allergic conditions, such as asthma and hay fever.
Paul Rasmussen, MD, Chairman of the LEO Foundation, pointed out: “Atopic dermatitis is one of the most common inflammatory disorders in children. It is the hope of the LEO Foundation that Dr. Guttman’s research will help remedy the situation.”
Twenty children with atopic dermatitis will be recruited into the study and compared with 20 children without atopic dermatitis.
“Dr. Guttman is the ideal investigator to pursue this research,” said Mark Lebwohl, MD, Sol and Clara Kest Professor and Chair, Department of Dermatology, Icahn School of Medicine at Mount Sinai. “She has identified many of the key cytokines involved in the development of atopic dermatitis.” He added: “Prior to her work, the only systemic treatments available were potent immunosuppressive drugs associated with many side effects. Dr. Guttman’s work is critically important in opening the door to targeted therapies that block only small parts of the immune system.”
Dr. Guttman is collaborating on the grant with Amy S. Paller, MD, Chair of Dermatology, and Professor of Dermatology and Pediatrics Dermatology, at Northwestern University Feinberg School of Medicine in Chicago.
About the Department of Dermatology The Department of Dermatology at the Icahn School of Medicine at Mount Sinai provides outstanding care using the latest advances in dermatology care. Adult and pediatric patients are seen in the Dermatology Clinic, the Inpatient Consult Service, and Faculty Practice. The Department has several divisions, including General Dermatology, Clinical Trials Department, Dermatopathology, Dermatologic Surgery, and the Dermatology Research Laboratories. The Department has been involved in many leading clinical trials that have paved the way to the latest standards of care in dermatology diseases.
About the Mount Sinai Health System The Mount Sinai Health System is an integrated health system committed to providing distinguished care, conducting transformative research, and advancing biomedical education. Structured around seven member hospital campuses and a single medical school, the Health System has an extensive ambulatory network and a range of inpatient and outpatient services—from community-based facilities to tertiary and quaternary care.
The System includes approximately 6,600 primary and specialty care physicians, 12-minority-owned free-standing ambulatory surgery centers, over 45 ambulatory practices throughout the five boroughs of New York City, Westchester, and Long Island, as well as 31 affiliated community health centers. Physicians are affiliated with the Icahn School of Medicine at Mount Sinai, which is ranked among the top 20 medical schools both in National Institutes of Health funding and by U.S. News & World Report.
About the LEO Foundation The LEO Foundation was created in 1984 to secure Denmark-based LEO Pharma a long-term basis for the company's continued development as an independent, international and research-based pharmaceutical company. The LEO Foundation also supports selected research and knowledge dissemination projects that address basic issues in skin diseases: from international studies over scientific symposia to science-based knowledge dissemination and awareness campaigns. Emphasis is on major international dermatologic projects, in particular such that seek to address clinical and other particulars around people and patients that risk developing one or more skin diseases.