PITTSBURGH, July 10 – University of Pittsburgh researchers have received $2.17 million from the National Heart, Lung, and Blood Institute, part of the National Institutes of Health, to study the prevention and early treatment of acute lung injury. Also known as acute respiratory distress syndrome (ARDS), acute lung injury is a deadly condition that causes the lung to fail in critically ill patients either directly through injury to the lung, such as pneumonia, or indirectly related to another illness.
“Many serious illnesses harm the lung, even when that illness starts elsewhere in the body. A trauma patient may develop ARDS as a result of blood loss or treatments. Severe infection, even outside of the lung, is also a major trigger for ARDS,” said Donald. M. Yealy, M.D., professor and chair of Pitt’s Department of Emergency Medicine. Pitt and UPMC investigators recently published in the New England Journal of Medicine a landmark study that brought new insights into early treatment of sepsis, a deadly form of infection. Dr. Yealy and co-lead investigator Derek C. Angus, M.D., M.P.H., Distinguished Professor and Mitchell P. Fink Chair, Department of Critical Care Medicine at Pitt, are members of the steering committee for the Pennsylvania region of the multi-center Prevention and Early Treatment of Acute Lung injury (PETAL) network.
The network, which includes a unique combination of emergency physicians and critical care specialists, will conduct clinical trials to prevent, treat and improve the outcome of patients with ARDS.
“Once lung injury is embedded, it often causes death or long-term damage. Our goal is to recognize the onset of ARDS and treat it before it can do serious harm to the lung,” Dr. Angus said.
Other collaborating and clinical PETAL centers include Penn State University-Hershey Medical Center, University of Colorado, University of California-San Francisco, Harvard University, Tufts University, University of Washington-Seattle, University of Utah-Intermountain Health Center, Wake Forest University, Vanderbilt University, Mount Sinai Medical Center, University of Michigan, Cleveland Clinic and Ohio State University.