SAGE Labs Launches CRISPR/Cas9 Reagents for Genetic Engineering

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SAGE Labs Launches CRISPR/Cas9 Reagents for Genetic Engineering

CRISPR/Cas9 system allows researchers to quickly and precisely edit DNA

ST. LOUIS, MO. – July 7, 2014 – SAGE Labs Inc., a leading provider of in vivo products, services and technologies in the field of genome engineering, today launched its SAGEspeed CRISPR/Cas9 reagents. These reagents enable researchers to quickly and easily perform genetic engineering in animal models, such as mice and rats, as well as cell lines.

Since 2009, SAGE Labs has been using targeted nucleases, including CRISPR/Cas9 and zinc finger nucleases, to perform genetic engineering in mice, rats, and rabbits as part of their SAGEspeed custom model generation service. With the launch of SAGEspeed CRISPR/Cas9 reagents, SAGE is now making available these same custom-designed and validated reagents to the research community.

SAGEspeed CRISPR/Cas9 reagents are available in two different formats. Microinjection-ready reagents come ready-to-inject, prepared in microinjection buffer and at SAGE’s own optimized concentrations for animal model generation. Reagents designed for use in cell lines are also available.

David Smoller, PhD., CEO of SAGE Labs, explained “CRISPR/Cas9 is an exciting new tool for fast and precise gene editing. While assembly of the CRISPR reagents is relatively simple, design and construction of reagents that perform well can be challenging. Our scientists have amassed a wealth of experience designing and validating nuclease-based gene editing tools for over five years, and we’re tremendously excited to be able to share our expertise with the scientific community by providing the same quality reagents that we use."

SAGEspeed CRISPR/Cas9 reagents are provided at three different levels of validation. SAGEspeed Validated reagents include project-specific design and validation of nuclease activity. SAGE will construct up to five designs and will provide the best performer. Validated+ reagents also include tools to assess potential off target effects. A basic package that lacks the design and validation services is also available for price conscious researchers.

The reagents are available today. More information can be found by visiting:

About Sage Labs

SAGE® Labs is a world-class provider of next-generation research models and transgenic support services. Using proprietary platform technologies, such as Zinc Finger Nucleases (ZFN) and the CRISPR/CAS9 system for genome engineering, SAGE produces complex in vivo research models in half the time as models produced using conventional technologies. For more information, visit

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