SENOMYX ANNOUNCES CONTINUED INCLUSION IN THE RUSSELL 2000 AND RUSSELL 3000 INDEXES

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SAN DIEGO, CA – June 28, 2011 – Senomyx, Inc. (NASDAQ: SNMX), a leading company focused on using proprietary taste receptor technologies to discover and develop novel flavor ingredients for the food, beverage, and ingredient supply industries, announced today its continued inclusion in the Russell 3000? Index following Russell Investments' annual reconstitution of its comprehensive set of U.S. and global equity indexes on June 24, 2010. Senomyx is also included in the Russell 2000? Index, a subset of the Russell 3000 composed of small-cap stocks.

"Senomyx is pleased that we will continue to be listed in the Russell 2000 and 3000 Indexes, which are among the most prestigious stock market indexes," stated Kent Snyder, Chief Executive Officer of the Company.  “We believe our Russell membership reflects the numerous advances achieved by Senomyx during the past year.  These include the establishment of two new collaborations and the extension of existing agreements, regulatory approval for two Bitter Blockers, and the issuance of more than 50 new patents covering Senomyx’s technologies and compositions, as well as the expansion of commercialization efforts by three of our partners.”

Annual reconstitution of Russell’s U.S. indexes captures the 4,000 largest U.S. stocks as of the end of May, ranking them by total market capitalization. Membership in the Russell 3000, which remains in place for one year, means automatic inclusion in either the large-cap Russell 1000 Index or small-cap Russell 2000 Index, as well as the appropriate growth and value style indexes.  Russell determines membership for its equity indexes primarily by objective, market-capitalization rankings and style attributes.

The Russell 3000 also serves as the U.S. component to the Russell Global Index.  Russell indexes are widely used by investment managers and institutional investors for index funds and as benchmarks for both passive and active investment strategies.

About Senomyx, Inc. (www.senomyx.com)

Senomyx is using proprietarytaste receptortechnologies to discover and developnovel flavor ingredients. These include new flavors such as Savory Flavors and Cooling Flavors, as well as flavor modulators such as Bitter Blockers and enhancers of Sweet and Salt tastes. Senomyx is also engaged in a new effort to discover and develop natural high-potency sweeteners. The Company hasproduct discovery and development collaborationswith global food, beverage, and ingredient supply companies, some of which are currently marketing products that contain Senomyx’s flavor ingredients. For more information, please visitwww.senomyx.com.

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding the potential uses for S6821 and S7958, ongoing activities related to the evaluation and possible future commercialization of S6821 by Senomyx collaborators, the potential to collaborate with new partners for the commercialization of S6821 and S7958, and the scope and duration of intellectual property protection provided by this new patent. Risks that contribute to the uncertain nature of the forward-looking statements include: Senomyx is dependent on its product discovery and development collaborators for all of Senomyx’s revenue; Senomyx may not enter into any new collaborations related to its bitter blockers; Senomyx is dependent on its current and any potential future collaborators to develop and commercialize S6821 and S7958; Senomyx collaborators may not elect to commercialize any Senomyx bitter blocker or the commercialization may be limited; Senomyx may be unable to protect its intellectual property and proprietary technology and to maintain and enforce its patents and licensing arrangements with various third party licensors; Senomyx may be unable to define the scope and validity of patent protection for products and technologies; and Senomyx’s ability to compete in the flavor ingredients market may decline if Senomyx does not adequately protect its proprietary technologies. These and other risks and uncertainties are described more fully in Senomyx’s most recently filed SEC documents, including its Annual Report on Form 10-K and Quarterly Report on Form 10-Q, under the headings “Risks Related to Our Business” and “Risks Related to Our Industry.” All forward-looking statements contained in this press release speak only as of the date on which they were made. Senomyx undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

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