SENOMYX GRANTED U.S. PATENT COVERING THE USE OF S2383, A HIGHLY EFFECTIVE ENHANCER OF THE SWEETENER SUCRALOSESenomyx Further Exp

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SAN DIEGO, CA – April 25, 2011 – Senomyx, Inc. (NASDAQ: SNMX), a leading company focused on using proprietary technologies to discover and develop novel flavor ingredients for the food, beverage, and ingredient supply industries, announced today that the Company has been granted U.S. Patent No. 7,928,111 covering foods and beverages containing S2383, a highly effective enhancer of the sweetener sucralose.

In particular, the issued patent includes composition claims covering S2383 and its analogs. S2383 is intended to enhance the taste of sucralose, a high-intensity sweetener used in a wide variety of products such as baked goods, cereals, desserts, dairy products, and confectionaries. Use of S2383 allows the amount of sucralose in these products to be reduced by up to 75% while maintaining the desired sweet taste. By enabling the reduction of sucralose, S2383 may allow manufacturers to decrease their costs of goods and improve the taste of certain products.

"Our pioneering research at Senomyx represents some of the most innovative work in the field of flavor technology," said Don Karanewsky, Ph.D., Senior Vice President and Chief Scientific Officer of the Company. "We are very pleased with the issuance of this key U.S. patent for one of our sweetness enhancers, and we believe it speaks to Senomyx's leadership in the identification and development of products that can substantially reduce the use of added sweeteners in a broad range of food and beverage applications."

Firmenich SA, a global leader in providing ingredients and flavor systems to major consumer companies, has exclusive worldwide rights to market S2383 as either a stand-alone ingredient or as part of a flavor system in all food and beverage product categories.

"We are very pleased to receive patent coverage for S2383, a unique new flavor ingredient that is a valuable asset for Senomyx," said Kent Snyder, Chief Executive Officer of the Company. "Firmenich has initiated sales of commercial quantities of S2383 and is currently engaged in marketing activities with additional major clients. The feedback from potential customers regarding the taste profile and other characteristics has been very favorable, and we're looking forward to the introduction of a variety of products containing S2383."

As of March 31, 2011, Senomyx was the owner or exclusive licensee of 239 issued patents and several hundred pending patent applications in the U.S., Europe, and numerous other countries. The Company's patents and patent applications include claims regarding proprietary technologies for the discovery of novel flavor ingredients, as well as composition and usage claims for new flavors and flavor modulators.

About Senomyx, Inc. (www.senomyx.com)

Senomyx is a leading company using proprietarytaste receptortechnologies to discover and developnovel flavor ingredientsin the savory, sweet, salt, bitter, and cooling areas. The Company hasproduct discovery and development collaborationswith global food, beverage, and ingredient supply companies, some of which are currently marketing products that contain Senomyx's flavor ingredients. For more information, please visitwww.senomyx.com.

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding the potential uses for S2383, Firmenich's ongoing activities related to the commercialization of S2383 and Senomyx's intention of maintaining existing patents and patent applications and pursuing further patent protection for new discoveries and inventions, including S2383. Risks that contribute to the uncertain nature of the forward-looking statements include: Senomyx is dependent on its product discovery and development collaborators for all of Senomyx's revenue; Senomyx is dependent on Firmenich to develop and commercialize S2383; Senomyx may be unable to protect its intellectual property and proprietary technology and to maintain and enforce its patents and licensing arrangements with various third party licensors; Senomyx may be unable to define the scope and validity of patent protection for products and technologies; and Senomyx's ability to compete in the flavor ingredients market may decline if Senomyx does not adequately protect its proprietary technologies. These and other risks and uncertainties are described more fully in Senomyx's most recently filed SEC documents, including its Annual Report on Form 10-K and Quarterly Report on Form 10-Q, under the headings "Risks Related to Our Business" and "Risks Related to Our Industry." All forward-looking statements contained in this press release speak only as of the date on which they were made. Senomyx undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

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News Source : SENOMYX GRANTED U.S. PATENT COVERING THE USE OF S2383, A HIGHLY EFFECTIVE ENHANCER OF THE SWEETENER SUCRALOSESenomyx Further Expands Its Intellectual Property Portfolio Regarding the Discovery, Composition, and Use of Novel Flavor Ingredients