SENOMYX, INC. FOURTH QUARTER AND FISCAL YEAR-END 2010 EARNINGS CONFERENCE CALL SCHEDULED FOR MARCH 3, 2011

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SAN DIEGO, CA – February 11, 2011 – Senomyx, Inc. (NASDAQ: SNMX) will release its financial results for the fourth quarter and fiscal year ended December 31, 2010 on Thursday, March 3, 2011 before the opening of the U.S. financial markets. The Company will also host a conference call with a live Internet broadcast that will provide a corporate update and a review of its fourth quarter and year-end results on the same day at 11:00 a.m. Eastern Time (8:00 a.m. Pacific Time).

To participate in the live conference call, U.S. residents should dial 888-713-4217, and international callers should dial 617-213-4869 at least 10 minutes prior to the call start time. The participant passcode for this conference call is 68722634. Participants may pre-register for the call at anytime, including up to and after the call start time, at https://www.theconferencingservice.com/prereg/key.process?key=PCYGUVHB7. Pre-registrants will be issued a pin number to use when dialing into the live call, which will provide quick access to the conference.

To access the live Internet broadcast or a subsequent archived recording, please log onto the Investor Relations section of Senomyx's website at http://investor.senomyx.com. The archived webcast will be available for 30 days following the presentation. Please connect to Senomyx's website prior to the start of the webcast to ensure adequate time to download any software that may be necessary.

About Senomyx, Inc. (www.senomyx.com)
Senomyx is a leading company using proprietarytaste receptortechnologies to discover and developnovel flavor ingredientsin the savory, sweet, salt, bitter, and cooling areas. The Company hasproduct discovery and development collaborationswith global food, beverage, and ingredient supply companies, some of which are currently marketing products that contain Senomyx’s flavor ingredients. For more information, please visitwww.senomyx.com.

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