SENOMYX TO WEBCAST CORPORATE PRESENTATION AT THE 10TH ANNUAL NEEDHAM HEALTHCARE CONFERENCE

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SAN DIEGO, CA – March 29, 2011 – Senomyx, Inc. (NASDAQ: SNMX), a leading company focused on using proprietary taste receptor technologies to discover and develop novel flavor ingredients for the food, beverage, and ingredient supply industries, announced today that Kent Snyder, the Company's Chief Executive Officer, and Tony Rogers, Vice President and Chief Financial Officer, will present a corporate overview on Tuesday, April 5, 2011 at 1:20 p.m. Eastern Time (10:20 a.m. Pacific Time) during the 10th Annual Needham Healthcare Conference. The conference is taking place at the New York Palace Hotel in New York, NY. During the presentation, Mr. Snyder and Mr. Rogers will discuss corporate developments including the Company's pipeline of novel flavor ingredients and its business strategy.

To access the live presentation or a subsequent archived recording, please log onto Senomyx's website athttp://www.senomyx.comand click on the "Investor Relations" tab. The archived webcast will be available for 30 days following the presentation. Please connect to Senomyx's website prior to the start of the webcast to ensure adequate time to download any software that may be necessary.

About Senomyx, Inc. (www.senomyx.com)

Senomyx is a leading company using proprietarytaste receptortechnologies to discover and developnovel flavor ingredientsin the savory, sweet, salt, bitter, and cooling areas. The Company hasproduct discovery and development collaborationswith global food, beverage, and ingredient supply companies, some of which are currently marketing products that contain Senomyx's flavor ingredients. For more information, please visitwww.senomyx.com.

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