Type 2 Diabetes Research: Connexios Life Sciences and Boehringer Ingelheim Enter Agreement for Novel AMPK Activators

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Bangalore, India, and Ingelheim, Germany, May 6, 2014 - Connexios Life Sciences, a Bangalore based biotechnology company, and Boehringer Ingelheim, one of the world's leading pharmaceutical companies, today announced an exclusive global research collaboration agreement for AMPK agonists for the treatment of patients with Type 2 Diabetes.

As part of the agreement, Boehringer Ingelheim obtains global rights to CNX-012, Connexios Life Sciences’ program on AMPK activators. The program includes CNX-570 and other compounds in early pre-clinical development. Boehringer Ingelheim will be responsible for all further development and commercialization of the candidates from the AMPK program. Further terms and financial details were not disclosed.

"As a pure research-driven organization from India, we believe that the agreement with Boehringer Ingelheim is a big validation of both our scientific approach and capabilities as well as of our business model.", commented Suri Venkatachalam, CEO and Founder of Connexios. "CNX-012 is one of our flagship programs which leverages our Network Biology approach and platform and we are extremely pleased to be working with Boehringer Ingelheim to advance candidates from this program. We strongly believe that the collaboration will yield best-in-class activators of this exciting but challenging target and ultimately result in better therapies for patients of Type 2 Diabetes who also suffer from the burden of several other cardiometabolic co-morbidities."

"Partnering is key to our business strategy and the partnership with Boehringer Ingelheim who have shown a strong commitment to the therapeutic area of metabolic diseases is an important milestone for Connexios. With our strengths in disease biology and drug discovery, we see great complementarity between the organizations and look forward to building on this relationship in future." added Shobha Vijayaraghavan, Vice President, Business Development of Connexios Life Sciences.

Commenting on the agreement, Michel Pairet, Senior Vice President and Global Head of Research and Development at Boehringer Ingelheim said: "We are extremely pleased to enter into this agreement with Connexios, a company recognised as experts in their field, which will further strengthen our discovery and development efforts in the area of cardiometabolic diseases."

About CNX-012 and CNX-012-570
CNX-012-570 is the lead candidate from the Connexios program of AMPK activators that directly activate specific isoforms of the protein, designed and selected to bring about a robust impact on the cellular energetics and redox balance across key cell types and tissues. Connexios has shown beneficial outcomes from target modulation across the liver, muscle, adipose and other relevant tissues in preclinical studies across several animal models of disease. The CNX-012 program comprises several other compounds like CNX-012-570 which cover a wide chemistry and patent space.

About Connexios Life Sciences
Connexios Life Sciences is an early stage Drug discovery and development company powered by a unique Network Biology Platform. Connexios is pursuing several best-in-class programs at different stages of preclinical discovery and development for Metabolic disease and diseases related to NASH and Fibrosis, while also seeking to progress some of its candidates for T2DM and metabolic disorders into the clinic.

For more information about Connexios, please visit www.connexios.com.

About Boehringer Ingelheim
The Boehringer Ingelheim group is one of the world’s 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, Boehringer Ingelheim operates globally with 142 affiliates and a total of more than 47,400 employees. The focus of the family-owned company, founded in 1885, is researching, developing, manufacturing and marketing new medications of high therapeutic value for human and veterinary medicine.

Taking social responsibility is an important element of the corporate culture at Boehringer Ingelheim. This includes worldwide involvement in social projects, such as the initiative “Making more Health” and caring for the employees. Respect, equal opportunities and reconciling career and family form the foundation of the mutual cooperation. In everything it does, the company focuses on environmental protection and sustainability.

In 2013, Boehringer Ingelheim achieved net sales of about 14.1 billion euros. R&D expenditure corresponds to 19.5% of its net sales.

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