The World’s First Ever Online Hub Dedicated To Cancer Anorexia-Cachexia Syndrome Goes Live.

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The site will offer a much needed place where health care providers can find and share state of the art knowledge on this common and multifactorial syndrome that affects up to 80 per cent of cancer patients

Salerno, Italy, January 8th 2013 - (PressReleasePoint) - CancerCachexiaHub” ( is a new place where state-of-the-art knowledge on this wasting disease is brought together and shared. The website – thanks to the support and collaboration of a Board of Scientific Experts on the syndrome – is intended to draw interest and knowledge about CACS, and is targeted at all health care providers – physicians, nurses, nutritionists – dedicated to providing integrated care to their cancer patients.
Cancer Anorexia-Cachexia Syndrome (CACS) is a multifactorial syndrome that has a negative impact on the functional performance, quality of life and prognosis of cancer patients. It is defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that is unable to be fully reversed by conventional nutritional support and leads to progressive functional impairment. It is characterized by a collection of signs and symptoms that include weight loss, poor appetite, fatigue, reduced functional performance and chronic inflammation.1,6 The occurrence of CACS is high, especially in patients with advanced cancer, accounting for 40%-80% depending on the tumor type. Nonetheless, CACS is often underdiagnosed and remains an unmet medical need.6,7 Despite its major impact, current levels of awareness and knowledge sharing on CACS is low among health care providers, often confined torestricted specialized environments, such as palliative care centers and scientific congresses.
CACS, therefore, represents today an important unmet medical need in cancer patient care.
“Today there is a major need for the health care community to be aware of the importance and prevalence of CACS, and to have a better understanding of the pathophysiology behind the different components of this syndrome – states Jose M. Garcia, Assistant Professor at Baylor College of Medicine and member of the Scientific Board of the hub ­– Within this context, there is clearly a strong need to have a central place like CancerCachexiaHub where HCPs can access valuable resources in order to educate other HCPs as well as patients and their families. This will allow for improved assessment, diagnosis and staging, and to better manage the different options that are available to treat CACS.”

WWW.CANCERCACHEXIA.COM: Contents & services
1. Scientific Board: provides interviews, biography and information on the CancerCachexiaHub Scientific Board. Furthermore, it collects editorial articles written by the Board. 2. Cancer Cachexia Guide: represents consensus-and evidence-based clinical practice guidelines for the management of CACS in advanced cancer patients. 3. News & Updates: a collection of News, Meetings and Conferences dedicated to Cancer Anorexia-Cachexia Syndrome. 4. Resource: contains interviews, downloadable materials, slide kits and videos dedicated to Cancer Anorexia Cachexia Syndrome plus a collection of video interviews from the Scientific Board.

A Board of Scientific Experts: Egidio Del Fabbro, MD - Jose M. Garcia, MD, PhD - Jane Hopkinson Professor of Nursing
“Our commitment to this initiative – state the three Experts - is to help health care providers find guidance and answers in their approach to CACS and respond to their need for information and resources. Ultimately, collaborating on the creation of the Hub, our aim is to increase the focus on CACS in order to better help patients and their relatives. For this reason, from 2014, we plan to make a section available entirely dedicated to patients and their careers."

1. Fearon K et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 2011;12:489–95
2. Fearon K et al. Understanding the mechanisms and treatment options in cancer cachexia. Nat Rev Clin Oncol 2013;10:90–9
3. Benner A et al. Cancer anorexia-cachexia syndrome (CACS) is under-recognized among patients with metastatic non-small cell lung cancer (MNSCLC). Support Cancer Care DOI 10.1007.s00520-013-1798-3. MASCC 2013
4. Bennani-Baiti N et al. What is cancer anorexia-cachexia syndrome? A historical perspective. J R Coll Physicians Edinb 2009;39:257–62
5. Vaughan VC et al. Cancer cachexia: impact, mechanisms and emerging treatments. J Cachexia Sarcopenia Muscle 2013;4:95–109
6. Del Fabbro E, Inui A, Strasser F. Cancer Cachexia. Springer Healthcare, 2012
7. von Haehling S et al. Cachexia as a major underestimated and unmet medical need: facts and numbers. J Cachexia Sarcopenia Muscle 2010;1:1–5

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